Microdosing Guide

Table of Contents

• 1. Introduction and Overview
• 2. Understanding Microdosing
• 3. Research-Based Benefits
• 4. Delivery Methods
• 5. Evidence-Based Protocols
• 6. Maximizing Success
• 7. Safety Considerations
• 8. Frequently Asked Questions
• 9. Client Experiences
• 10. Professional Resources
• 11. Microdosing Tracker

1. Introduction and Overview

Microdosing represents an emerging approach to mental health and wellness that involves taking sub-perceptual amounts of mushrooms that contain psilocybin. This practice has gained significant attention in the mental health community for its potential to support individuals dealing with depression, anxiety, loneliness, PTSD, addiction and other health challenges.

What is Microdosing?

Microdosing is the practice of taking very small, non-psychoactive sub-hallucinogenic amounts of mushrooms that contain psilocybin. These doses are specifically calibrated to remain “sub- perceptual,” meaning users experience no psychoactive effects, visual changes, or altered consciousness. Instead, the benefits occur at a cellular level, potentially promoting neurogenesis and supporting mental health recovery. The goal is not to create a “high” or hallucinogenic experience, but rather to gently support the brain and body on a cellular level.

Psilocybin has been shown to encourage neurogenesis — the growth of new neurons in the brain — which is closely linked to learning, memory, and reducing symptoms of depression. Many people describe microdosing as a way to feel more balanced, open, and connected without feeling altered.

Potential Benefits of Microdosing

Research and patient experiences show that consistent microdosing may support:

• • Improved mood and outlook – more peace, calm, and optimism
• • Reduced anxiety and stress – greater ease in daily life
• • Focus and productivity – enhanced concentration and workflow
• • Creativity and problem solving – new perspectives and ideas
• • Energy and motivation – feeling more awake and inspired
• • Emotional resilience – less reactivity to triggers, more emotional balance
• • Connection – openness in relationships, increased sense of empathy
• • Nervous system health – cellular protection and regeneration

Legal Context

This information pertains to legal psilocybin therapy services available in Colorado, where certain psilocybin practices have been decriminalized under state law. All services comply with Colorado state regulations. If you are outside Colorado, the legal context from which we can be in relationship is Harm Reduction and Public Safety. This means you only pay for consultation not product. Please be clear on this. We gift/share product and charge you for our expertise/ consultations.

2. Understanding Microdosing

The Science Behind Microdosing

Recent research suggests that psilocybin may promote neurogenesis—the growth of new brain cells and neural connections. This process has been linked to improvements in three key cognitive areas:

• – Learning capacity
• – Memory function
• – Depression recovery

How It Works

Unlike traditional antidepressants that work on neurotransmitter systems, psilocybin appears to work by:

• – Promoting neural plasticity
• – Encouraging new neural pathway formation
• – Supporting cellular regeneration in the brain
• – Enhancing connectivity between brain regions

3. Research-Based Benefits

Clinical Research Findings

Emerging studies and clinical observations have documented the following potential benefits of microdosing protocols:

Mood and Emotional Well-being (26.6% of reported benefits)

• – Improved overall mood and emotional stability
• – Reduced symptoms of depression and anxiety
• – Enhanced sense of well-being and life appreciation
• – Better emotional regulation and resilience

Cognitive Enhancement (14.8% of reported benefits)

• – Improved focus and concentration
• – Enhanced mindfulness and present-moment awareness
• – Better attention span and mental clarity
• – Increased conscious awareness

Creative and Problem-Solving Benefits (12.9% of reported benefits)

• – Enhanced creativity and innovative thinking
• – Improved perspective-taking abilities
• – Better problem-solving capabilities
• – Increased curiosity and openness to new ideas

Self-Efficacy and Motivation (11.3% of reported benefits)

• – Improved motivation and ambition
• – Enhanced productivity and goal achievement
• – Better self-care practices
• – Increased confidence and sense of personal agency

Energy and Physical Well-being (10.5% of reported benefits)

• – Improved energy levels and alertness
• – Better sleep quality
• – Enhanced physical stamina
• – Reduced fatigue and mental fog
• Social Benefits (7.6% of reported benefits)
• – Improved empathy and emotional connection- Enhanced communication skills
• – Better relationship satisfaction
• – Increased social comfort and confidence

*Many are taking microdosing supplements as preventative medicine for any brain-related decline diseases. For those who do not have any health-related issues, many microdose to learn a new language or musical instrument easier/faster. There are many reasons why someone may want to microdose.

4. Delivery Methods

Microdosing can be taken in a variety of forms, all designed to be safe, convenient, and effective:

• • Capsules – lab-tested psilocybin paired with organic Lion’s Mane mushroom
• • Tinctures – liquid extracts for easy dosing and absorption
• • Gummies, chocolates, or drink packets – discreet and simple options
• • Non-psilocybin blends – available for those outside Colorado or for patients who prefer an alternative

During your consultation, we will discuss which option best suits your goals, lifestyle, and health needs.

Professional-Grade Options

A. Precisely Dosed Capsules

• – Laboratory-tested psilocybin content
• – Combined with organic Lion’s Mane mushroom
• – Standardized dosing for consistent results
• – Quality-assured production methods

B. Liquid Tinctures

• – Sublingual administration for faster absorption
• – Precise dosage control
• – Easy to adjust based on individual needs
• – Discreet and convenient

C. Alternative Formats

• – Gummies and chocolates (available upon request)
• – Drink packets for liquid consumption
• – Raw material for those preferring traditional methods

Quality Assurance

All products undergo rigorous testing for:

• – Potency verification
• – Contaminant screening
• – Microbial safety
• – Heavy metal analysis

5. Evidence-Based Protocols

Microdosing Protocols

There is no “one-size-fits-all.” Different protocols may be recommended depending on your health and goals.

• • Stamets Stack – 4 days on, 3 days off (psilocybin, Lion’s Mane, and niacin)
• • Fadiman Protocol – every 3rd day, with reflection days in between
• • Customized Protocols – adapted for your body, mood, and intentionsWhat matters most is consistency and tracking your experience. Patients often keep a simple journal of mood, sleep, focus, and energy to notice patterns over time.

A. The Stamets Stack Protocol

Developed by mycologist Paul Stamets, this protocol combines:

• – Psilocybin: 100mg (active dose)
• – Lion’s Mane: 500mg-1g (neurogenesis support)
• – Niacin (B3): 50-200mg (vascular enhancement)

Schedule:

• – Days 1-4: Take stack
• – Days 5-7: Rest period
• – Repeat cycle for 4 weeks
• – Reset: 2-4 weeks complete break

B. The Fadiman Protocol

Based on research by Dr. James Fadiman:

• – Day 1: Microdose day
• – Day 2: Transition/observation day
• – Day 3: Rest day (baseline assessment)
• – Cycle: Continue for 4-8 weeks
• – Reset: 2-4 weeks break

C. Personalized Protocols

Individual protocols may vary based on:

• – Personal response patterns
• – Mental health goals
• – Lifestyle factors
• – Other medications or supplements

Dosage Guidelines:

• – Starting dose: 50-100mg
• – Standard microdose: 100-125mg
• – Adjusted range: 50-250mg (based on individual response)

6. Maximizing Success

Intentional Practice

Microdosing is most effective when approached with clear intention:

• 1. Set Clear Goals: Define what you hope to achieve
• 2. Create Ritual: Establish a mindful dosing routine
• 3. Track Progress: Monitor changes in mood, cognition, and behavior
• 4. Regular Check-ins: Assess progress weekly

Timing Recommendations

Morning Dosing (Recommended)

• – Take on empty stomach or after light breakfast
• – Optimal time: 10:00 AM
• – Allows for daytime integration of effectsEvening Dosing (Alternative)
• – Suitable for those interested in dream work
• – May enhance sleep quality
• – Take 1-2 hours before bedtime

*If you are in need, you can take a third dose mid-day. This is for someone who is going through something painful or traumatic or just want to work with the medicine this way.

Integration Practices

Enhance microdosing benefits through:

• – Mindfulness meditation
• – Journaling and self-reflection
• – Regular exercise and movement
• – Adequate sleep and nutrition
• – Therapy or counseling support

How to Be Successful

Microdosing is not just about taking a supplement — it’s about working with intention. Patients often find the best results when they:

• • Set a clear intention before each dose
• • Take notes on their experiences
• • Integrate insights through meditation, movement, or journaling
• • Allow time for rest and reset between cycles

7. Safety Considerations

General Safety Profile

Microdosing typically has a favorable safety profile when properly administered. However, certain considerations apply:

Contraindications

Medical Conditions:

• – Active psychotic disorders
• – Severe cardiovascular conditions
• – Pregnancy or breastfeeding
• – History of bipolar disorder (requires medical supervision)

Medication Interactions:

• – MAO inhibitors
• – Certain antidepressants
• – Blood thinners (due to niacin component) – you do not have to take niacin with microdosing

Niacin Flush Information

Some individuals may experience a “niacin flush”:

• – Temporary reddening of skin
• – Warm, tingling sensation
• – Duration: 30-60 minutes
• – Harmless but can be uncomfortable
• – Minimized by gradual dose increases

Professional Consultation

Always consult with a healthcare provider before beginning a microdosing protocol, especially if you:

• – Take prescription medications
• – Have existing medical conditions
• – Are new to psychedelic therapy
• – Experience any adverse effects

Microdosing may not be suitable for everyone. Please inform me if you are currently taking prescription medications, have a history of severe mental health conditions, or are pregnant/breastfeeding.

8. Frequently Asked Questions

9. Client Experiences

“I have experienced an overall lift in mood and less reactivity to emotional triggers. I find it opens me up to greater connection with my clients while maintaining healthy boundaries. The effects feel like a conversation between the plant medicine, my body, and my spirit.”

“After starting the protocol, I immediately noticed increased energy and clarity. It has helped me maintain positive outlook even during stressful times. My clients are reporting similar experiences.”

“I feel like I have emerged from a fog of depression and anxiety. For the first time in months, I am tackling projects that once felt overwhelming. I have more skill in managing minor depression when it arises.”

“There is more space in my field to have new experiences and responses. Old patterns of fear- based reactions have less presence in my decision-making process.”

10. Professional Resources

Consultation Services

Initial Consultation ($200)

• – 1-on-1 phone or zoom consultation
• – Comprehensive assessment
• – Personalized protocol development
• – Symptom survey and neurotransmitter evaluation
• – Ongoing support via phone/email

Comprehensive Package ($350)

• – Everything in initial consultation
• – Everything in Specialized Testing (below)

Specialized Testing

Mushroom Compatibility Testing ($299)

• – Analysis of 60+ psilocybin strains
• – Personalized strain recommendations
• – Optimal dosage guidelines
• – Other wellness suggestions to support

Advanced Therapeutic Options

Macrodose Healing Sessions ($3000-$5,500)

• – Comprehensive medical intake
• – Preparation sessions
• – 6-hour guided healing experience
• – Multiple integration sessions
• – Custom workbook and journaling materials
• – Price based on individual or couple rate

Educational Resources

Microdosing Guide and Tracker

• – Daily tracking templates
• – Progress assessment tools
• – Educational materials

Macrodosing Preparation Guide

• – Comprehensive preparation protocols
• – Integration strategies
• – Safety guidelines

*These are on DoctorLeta.com or are included when you schedule.

Professional Support

For questions before you schedule appointment:

• – Consultation Line: 831-222-0189 (text or call)
• – Website: DoctorLeTa.com
• – Secure Messaging: Signal app only (831-239-9326)

Scholarship Program

Financial assistance available for qualifying individuals. Donations to support access can be made through CoastalSanctuaryCollaborative.org or those needing assistance can apply.

Important Tracking Guidelines

Daily Documentation Should Include:

• – Mood and emotional state
• – Focus and cognitive clarity
• – Energy levels
• – Social interactions and comfort
• – Sleep quality and dreams
• – Creative insights or breakthroughs
• – Any unusual experiences

4-Week Assessment Points:

• – Overall mood improvements
• – Cognitive enhancement
• – Emotional breakthroughs
• – Need for protocol adjustments

Important Note

This guide is for educational purposes only and does not replace medical advice or therapy. If you are currently experiencing severe depression or thoughts of self-harm, please reach out to a mental health professional or call 988 for immediate support.

Psilocybin facilitation is available in Colorado under licensed providers such as myself. If you would like a macrodosing healing journey, you may come to Colorado or schedule a session in your home or I have a location in Brewster. Travel fees apply and legalities are slightly different.

11. Microdosing Tracker

If you want to use an “app”, click here. Otherwise, you can download my PDF, print and utilize.

You deserve to feel balanced, connected, and well. Microdosing may be one step toward that journey— and you don’t have to do it alone.